A new publication from Final International University on nanomedicine: study showed how to prevent toxicity due to nanoparticle-based drug delivery systems and improve recovery from a heart attack.

Polyamidoamine (PAMAM) dendrimer nanoparticles are efficient drug delivery vectors with clinical applications in nanomedicine. However, we showed previously that PAMAMs can compromise heart function, and strategies to mitigate cardiotoxicity would be beneficial.

In this study, we showed that use of the cardioprotective agents Losartan, Epidermal Growth Factor, or S-nitroso-Nacetylpenicillamine can improve recovery from a heart attack by inhibiting toxicity due to nanoparticle-based drug delivery system (a seventh-generation cationic PAMAM dendrimer).

These results will have significant benefits in the development of nanomedicine strategies.

https://www.bjbms.org/ojs/index.php/bjbms/article/view/10735